Identification of Micrornas Associated with Tamoxifen Resistance in Breast Cancer Review

This dissertation, “Identification of MicroRNAs Linked With Tamoxifen Resistance in Breast Cancer” by Lai-yee, Lau, 劉麗儀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is currently being offered pursuant to Innovative Commons: Attribution three. Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the writer.
Tamoxifen is the most widely used endocrine therapy for each early and innovative estrogen receptor (ER) positive breast cancer individuals. About half of the sufferers that at first reply to the antiestrogen become estrogen-independent and in the long run produce resistance to the treatment. The exact molecular mechanisms of tamoxifen resistance remain poorly understood. Dysregulation of microRNAs (miRNAs) has been frequently reported in breast cancer